Effect on 30-day mortality and duration of hospitalization of empirical antibiotic therapy in CRGNB-infected pneumonia

Abstract Background The objective of this study was to investigate whether unreasonable empirical antibiotic treatment (UEAT) had an impact on 30-day mortality and duration hospitalization in bacterial pneumonia caused by carbapenem-resistant gram-negative bacteria (CRGNB). Methods This a retrospective cohort involving CRGNB-infected pneumonia. All patients received targeted (TAT), they were divided into reasonable (REAT) UEAT according the (EAT) reasonable. data two groups compared analyze their influence time patients. Moreover, we also considered other variables that might be relevant conducted multivariable regression analysis Results collected 310 patients, most common bacterium is Acinetobacter baumannii (211/310 [68%]), rest Klebsiella pneumoniae (46/310 [15%]), Pseudomonas aeruginosa others (53/310 [17%]). Among them, 76/310 (24.5%) REAT. In risk factors, dementia, consciousness factors mortality, pulmonary disease, hemodynamic support at culture taken day recent surgery for longer hospital stay. showed not associated with REAT 9 76 (11.84%) 36 234 (15.38%) ( P = 0.447), respectively. Meanwhile, there difference between 0.023) EAT Conclusions while related which baumanniii accouned majority.